All functions

HMEC.chr10

Hi-C data from HMEC cell line - chromosome 10 at 500kb resolution

HMEC.chr22

Hi-C data from HMEC cell line - chromosome 22 at 500kb resolution

HiCcompare-package

HiCcompare

KRnorm()

Performs KR (Knight-Ruiz) normalization on a Hi-C matrix

MA_norm()

Perform MA normalization on a hic.table object

MD.plot1()

Visualize the MD plot before and after loess normalization

MD.plot2()

Visualize the MD plot.

NHEK.chr10

Hi-C data from NHEK cell line - chromosome 10 at 500kb resolution

NHEK.chr22

Hi-C data from NHEK cell line - chromosome 22 at 500kb resolution

SCN()

SCN normalization from Cournac 2012

brain_table

Hi-C data from two regions of the brain at 100KB resolution

centromere_locations

Locations of the centromeres for hg19

cooler

Hi-C data in the cooler format

cooler2bedpe()

Read a .cool file into R and output the data in BEDPE format

cooler2sparse()

Transform a .cool file to a sparse upper triangular matrix for input into hic_loess

create.hic.table()

Create hic.table object from a sparse upper triangular Hi-C matrix

filter_params()

Determine the A quantile cutoff to be used

full2sparse()

Transfrom a full Hi-C contact matrix to a sparse upper triangular matrix

get_CNV()

Function to get the locations of copy number variations

hg19_blacklist

BED file for hg19 blacklisted regions

hg38_blacklist

BED file for hg38 blacklisted regions

hic_compare()

Detect differences between two jointly normalized Hi-C datasets.

hic_diff()

Detect differences between two jointly normalized Hi-C datasets. OLD METHOD; USE hic_compare() instead

hic_loess()

Perform joint loess normalization on two Hi-C datasets

hic_simulate()

Simulate a Hi-C matrix and perform HiCcompare analysis on it

hicpro2bedpe()

Convert HiC-Pro results to BEDPE format

hmec.IS

Hi-C data from HMEC cell line - chromosome 22 at 500kb resolution

make_InteractionSet()

Convert HiCdiff results to InteractionSet object

manhattan_plot()

Create a Manhattan plot for the results of HiCcompare

nhek.IS

Hi-C data from NHEK cell line - chromosome 22 at 500kb resolution

remove_centromere()

Function to remove centromere columns and rows from a full Hi-C contact matrix

sim.other.methods()

Compare other normalization methods on simulated data

sim_matrix()

Simulate 2 Hi-C matrices with differences

sparse2full()

Transform a sparse upper triangular matrix to a full Hi-C contact matrix

split_centromere()

Function to split hic.table into 2 subsets at the centromere

total_sum()

Total sum normalization for a list of hic.table objects

visualize_pvals()

Function to visualize p-values from HiCcompare results